Mifune Masaki, Asahara Hatsuki, Hinokiyama Toyohiro, Liu Jian, Akizawa Hiromichi, Iwado Akimasa, Motohashi Noriko, Saito Yutaka
Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Chem Pharm Bull (Tokyo). 2002 Dec;50(12):1638-40. doi: 10.1248/cpb.50.1638.
The complex formation of In(3+)-tetrakis(4-N-methylpyridyl)-porphine (In-TMPyP) with albumin was studied by resonance Raman spectroscopy. Albumin coordinated to In(3+) through the -S(-) group(s). The photoreaction was investigated using the visible spectral change and In-TMPyP-thiourea complex was used as a model. It was demonstrated that the complex in a weak basic solution (pH 8.5) is excited by light and the excited complex converts oxygen to superoxide anion, which finally cleavages the porphine ring of In-TMPyP.
通过共振拉曼光谱研究了铟（Ⅲ）-四（4-N-甲基吡啶基）卟啉（In-TMPyP）与白蛋白的络合物形成。白蛋白通过-S（-）基团与铟（Ⅲ）配位。利用可见光谱变化研究了光反应，并以In-TMPyP-硫脲络合物为模型。结果表明，在弱碱性溶液（pH 8.5）中的络合物受光激发，激发态络合物将氧气转化为超氧阴离子，最终裂解In-TMPyP的卟啉环。
