Tan Kian H, Purcell Wendy M, Heales Simon J R, McLeod Julie D, Hurst Roger D
Department of Neurochemistry, Institute of Neurology, University College of London, London WC1N 3BG, UK.
Neuroreport. 2002 Dec 20;13(18):2587-91. doi: 10.1097/00001756-200212200-00041.
Neuro-inflammation is characterized by immune cell infiltration across the blood-brain barrier, a process instrumental in neuronal cell death. In neuro-inflammation the blood-brain barrier is also damaged and the consequences of activated lymphocytes on the integrity of the blood-brain barrier is not well characterized. Utilizing an blood-brain barrier model we demonstrate that endothelial cell viability and barrier integrity are directly altered following lymphocyte exposure. The effect of activated lymphocytes is cell number dependent, mostly mediated by direct contact, and is not associated with the pro-inflammatory cytokine TNF-alpha. For the successful treatment of neuro-inflammatory disease, intervention of this direct effect at the blood-brain barrier is warranted.
神经炎症的特征是免疫细胞穿过血脑屏障浸润，这一过程在神经元细胞死亡中起重要作用。在神经炎症中，血脑屏障也会受损，而活化淋巴细胞对血脑屏障完整性的影响尚未得到充分描述。利用血脑屏障模型，我们证明淋巴细胞暴露后内皮细胞活力和屏障完整性会直接改变。活化淋巴细胞的作用取决于细胞数量，主要由直接接触介导，且与促炎细胞因子肿瘤坏死因子-α无关。为成功治疗神经炎症性疾病，有必要干预血脑屏障处的这种直接作用。
