“正常”尸体肾供体中的蛋白尿

Proteinuria in "normal" cadaver kidney donors.

作者信息

Steiner Robert, Chanchairujira Thawee, Leyden Sandra

机构信息

Lifesharing Community Organ and Tissue Donation, San Diego, CA, USA.

出版信息

Transplantation. 2002 Dec 27;74(12):1788-803. doi: 10.1097/00007890-200212270-00025.

DOI:10.1097/00007890-200212270-00025

PMID:12499899

Abstract

BACKGROUND

More information is needed about cadaver organ donor pathophysiology.

METHODS

We quantitated preprocurement, timed urine protein excretion in 23 "normal" cadaver kidney donors, and correlated results with urine protein dipstick readings and multiple other parameters. We also attempted to measure microalbuminia in 10 subjects.

RESULTS

Seventeen of 23 cadaver donors did not have detectable proteinuria (albuminuria) by urine dipstick testing but had 1,704+/-2,900 mg (mean+/-SD) of quantitated daily urine protein, which did not correlate with creatinine clearance or urine volume. Donors with head trauma had numerically more quantitated proteinuria (3,000+/-5,160 vs. 970+/-670 mg/day, P=0.13). Microalbumin varied from 3 to 34% of the total urine protein concentration.

CONCLUSIONS

Significant proteinuria as measured by quantitative collection techniques is often present in excellent cadaver kidney donors and is not detected by dipstick testing. It may be a marker of important terminal pathophysiologic events and deserves further study.

摘要

背景

关于尸体器官供体的病理生理学，需要更多信息。

方法

我们对23名“正常”尸体肾供体的术前定时尿蛋白排泄进行了定量，并将结果与尿蛋白试纸读数及其他多个参数进行了关联。我们还尝试对10名受试者进行微量白蛋白检测。

结果

23名尸体供体中有17名通过尿试纸检测未发现蛋白尿（白蛋白尿），但定量每日尿蛋白为1,704±2,900毫克（均值±标准差），这与肌酐清除率或尿量无关。头部受过创伤的供体定量蛋白尿在数值上更多（3,000±5,160与970±670毫克/天，P = 0.13）。微量白蛋白占总尿蛋白浓度的3%至34%不等。