你猜怎么着：血液中慢性13q14.3+/CD5-/CD23+淋巴细胞白血病，以及淋巴结中t(11;14)(q13;q32)+/CD5+/CD23-套细胞淋巴瘤！

Guess what: Chronic 13q14.3+/CD5-/CD23+ lymphocytic leukemia in blood and t(11;14)(q13;q32)+/CD5+/CD23- mantle cell lymphoma in lymph nodes!

作者信息

Lima Margarida, Pinto Luísa, Dos Anjos Teixeira Maria, Canelhas Aurea, Mota Alexandra, Cabeda José Manuel, Silva Cidália, Queirós Maria Luís, Fonseca Sónia, Santos Ana Helena, Brochado Paulo, Justiça Benvindo

机构信息

Service of Clinical Hematology, Hospital Geral de Santo António, Porto, Portugal.

出版信息

Cytometry B Clin Cytom. 2003 Jan;51(1):41-4. doi: 10.1002/cyto.b.10005.

DOI:10.1002/cyto.b.10005

PMID:12500296

Abstract

We report a case of a patient with two B-cell lymphoproliferative disorders: CD5(-)/CD23(+) B-cell chronic lymphocytic leukemia and CD5(+)/CD23(-) mantle cell lymphoma. These disorders were diagnosed simultaneously based on flow cytometry, immunohistochemistry, fluorescence in situ hybridization, and polymerase chain reaction-based molecular studies. The B-cell lymphocytic leukemia clone predominated in the blood and bone marrow, whereas the mantle cell clone predominated in lymph nodes.

摘要

我们报告了一例患有两种B细胞淋巴增殖性疾病的患者：CD5(-)/CD23(+) B细胞慢性淋巴细胞白血病和CD5(+)/CD23(-) 套细胞淋巴瘤。基于流式细胞术、免疫组织化学、荧光原位杂交以及基于聚合酶链反应的分子研究，这两种疾病被同时诊断出来。B细胞淋巴细胞白血病克隆在血液和骨髓中占主导地位，而套细胞克隆在淋巴结中占主导地位。