Lima Margarida, Pinto Luísa, Dos Anjos Teixeira Maria, Canelhas Aurea, Mota Alexandra, Cabeda José Manuel, Silva Cidália, Queirós Maria Luís, Fonseca Sónia, Santos Ana Helena, Brochado Paulo, Justiça Benvindo
Service of Clinical Hematology, Hospital Geral de Santo António, Porto, Portugal.
Cytometry B Clin Cytom. 2003 Jan;51(1):41-4. doi: 10.1002/cyto.b.10005.
We report a case of a patient with two B-cell lymphoproliferative disorders: CD5(-)/CD23(+) B-cell chronic lymphocytic leukemia and CD5(+)/CD23(-) mantle cell lymphoma. These disorders were diagnosed simultaneously based on flow cytometry, immunohistochemistry, fluorescence in situ hybridization, and polymerase chain reaction-based molecular studies. The B-cell lymphocytic leukemia clone predominated in the blood and bone marrow, whereas the mantle cell clone predominated in lymph nodes.
我们报告了一例患有两种B细胞淋巴增殖性疾病的患者：CD5(-)/CD23(+) B细胞慢性淋巴细胞白血病和CD5(+)/CD23(-) 套细胞淋巴瘤。基于流式细胞术、免疫组织化学、荧光原位杂交以及基于聚合酶链反应的分子研究，这两种疾病被同时诊断出来。B细胞淋巴细胞白血病克隆在血液和骨髓中占主导地位，而套细胞克隆在淋巴结中占主导地位。
