Celia Gerard, Osol George
Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington 05405, USA.
Am J Obstet Gynecol. 2002 Dec;187(6):1653-9. doi: 10.1067/mob.2002.127598.
Venoarterial communication describes the phenomenon whereby molecular signals in a vein directly influence an adjacent artery. The objective of this study was to investigate, in vitro, the existence of such a pathway in the uterine circulation of the rat.
Paired uterine vessels from late pregnant and virgin rats were pressurized and studied in a dual-perfusion vasograph. Veins were perfused with phenylephrine and endothelin-1, alone or in combination, and the vasoactive responses of both vessels were recorded.
Venous perfusion of phenylephrine resulted in concentration-dependent arterial, but not venous, constriction. Conversely, veins, but not arteries, demonstrated concentration-dependent constriction to intravenous endothelin-1. Superfusion of endothelin-1 constricted both vessels. Coperfusion of endothelin-1 and phenylephrine constricted the veins and attenuated the previously observed arterial response to intravenous phenylephrine.
The results of this study support the existence of venoarterial communication within the uterine circulation through an endothelin-1-sensitive pathway.
静脉-动脉通讯描述的是静脉中的分子信号直接影响相邻动脉的现象。本研究的目的是在体外研究大鼠子宫循环中是否存在这样一条通路。
对来自妊娠晚期大鼠和未孕大鼠的配对子宫血管进行加压，并在双灌注血管描记仪中进行研究。分别或联合用去氧肾上腺素和内皮素-1灌注静脉，并记录两根血管的血管活性反应。
去氧肾上腺素静脉灌注导致动脉出现浓度依赖性收缩，但静脉无此反应。相反，静脉而非动脉对静脉内注射内皮素-1呈现浓度依赖性收缩。内皮素-1的 superfusio 使两根血管均收缩。内皮素-1与去氧肾上腺素共同灌注使静脉收缩，并减弱了先前观察到的动脉对静脉注射去氧肾上腺素的反应。
本研究结果支持子宫循环中通过内皮素-1敏感通路存在静脉-动脉通讯。
