Iregbu K C, Ogunsola F T, Odugbemi T O
Department of Medical Microbiology & Parasitology, National Hospital, Garki, Abuja, Nigeria.
Niger Postgrad Med J. 2002 Sep;9(3):125-8.
Enterococcus faecalis is the most common of the Enterococcus genus causing infection, particularly urinary tract infections, worldwide. It is also a common cause of nosocomial infections and resistance to various antibiotics is on the increase worldwide. Thirty-five strains of E. Faecalis isolated from various clinical specimens (blood, wound swabs endocervical swabs but mostly urine) were screened for high-level aminoglycoside resistance. Their susceptibility nine antibiotics (ampicillin, gentamicin, streptomycin, vancomycin, tetracycline cotrimoxazole and chloramphenicol, ciprofloxacin and erthromycin) was also determined. All isolates were susceptible to Ampicillin and Vancomycin with MIC90 of 4microg/ml but resistant to Nalidixic acid with an MIC90>256microg/ml. Four (11%) of the isolates showed high-level resistance to Gentamicin while 11(32%) exhibited high-level resistance streptomycin after 24 hours incubation. It will appear that Ampicillin in combination with gentamicin but not streptomycin, can still be used empirically for the treatment of Enterococcal infections.
粪肠球菌是肠球菌属中最常见的引起感染的菌种，在全球范围内，尤其易引发尿路感染。它也是医院感染的常见病因，并且在全球范围内对各种抗生素的耐药性正在增加。从各种临床标本（血液、伤口拭子、宫颈拭子，但大多数是尿液）中分离出35株粪肠球菌，对其进行高水平氨基糖苷类耐药性筛查。还测定了它们对九种抗生素（氨苄西林、庆大霉素、链霉素、万古霉素、四环素、复方新诺明、氯霉素、环丙沙星和红霉素）的敏感性。所有分离株对氨苄西林和万古霉素敏感，MIC90为4μg/ml，但对萘啶酸耐药，MIC90>256μg/ml。4株（11%）分离株对庆大霉素表现出高水平耐药，而11株（32%）在培养24小时后对链霉素表现出高水平耐药。似乎氨苄西林联合庆大霉素而非链霉素，仍可凭经验用于治疗肠球菌感染。
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