Pál Endre, Kosztolányi Péter, Perlaky Petra
Pécsi Tudományegyetem, Altalános Orvostudományi Kar, Neurológiai Klinika.
Orv Hetil. 2002 Dec 1;143(48):2681-5.
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system causing severe disability via the progressive damage of white matter. Beyond physical signs cognitive dysfunction might be present as well. The aim of this study was to investigate the frequency and characteristics of brain atrophy and cognitive alterations. Significant cortical and subcortical atrophy was found on brain MRI of 30 MS patients included in this study comparing to healthy controls. Abnormal findings were detected in more than 60% of patients using a cognitive test battery. Generally, verbal abstraction, visuospatial orientation, attention, short-term memory was impaired and the psychomotor speed was decreased, even in the early stage of the disease. Depression-related complaints were found in 57% of this population. The Kurtzke scale, the atrophy of corpus callosum and widening of 3rd ventricle and Sylvian fissures were related to impaired cognitive performances. The authors would like to call attention to the early cognitive deficit and the need of treatment in MS.
多发性硬化症（MS）是一种中枢神经系统的自身免疫性疾病，通过白质的进行性损伤导致严重残疾。除了身体体征外，也可能存在认知功能障碍。本研究的目的是调查脑萎缩和认知改变的频率及特征。与健康对照组相比，本研究纳入的30例MS患者的脑部MRI显示出明显的皮质和皮质下萎缩。使用一套认知测试，在超过60%的患者中检测到异常结果。一般来说，即使在疾病早期，言语抽象、视觉空间定向、注意力、短期记忆也会受损，精神运动速度也会下降。在这一人群中，57%的人有与抑郁相关的主诉。库尔特克量表、胼胝体萎缩以及第三脑室和大脑外侧裂增宽与认知功能受损有关。作者希望引起人们对MS早期认知缺陷及治疗需求的关注。
