Ryberg C, Rostrup E, Stegmann M B, Barkhof F, Scheltens P, van Straaten E C W, Fazekas F, Schmidt R, Ferro J M, Baezner H, Erkinjuntti T, Jokinen H, Wahlund L-O, O'brien J, Basile A M, Pantoni L, Inzitari D, Waldemar G
Danish Research Center for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark.
Neurobiol Aging. 2007 Jun;28(6):955-63. doi: 10.1016/j.neurobiolaging.2006.04.008. Epub 2006 Jun 23.
Corpus callosum (CC) is the main tract connecting the hemispheres, but the clinical significance of CC atrophy is poorly understood. The aim of this work was to investigate clinical and functional correlates of CC atrophy in subjects with age-related white matter changes (ARWMC). In 569 elderly subjects with ARWMC from the Leukoaraiosis And DISability (LADIS) study, the CC was segmented on the normalised mid-sagittal magnetic resonance imaging (MRI) slice and subdivided into five regions. Correlations between the CC areas and subjective memory complaints, mini mental state examination (MMSE) score, history of depression, geriatric depression scale (GDS) score, subjective gait difficulty, history of falls, walking speed, and total score on the short physical performance battery (SPPB) were analyzed. Significant correlations between CC atrophy and MMSE, SPPB, and walking speed were identified, and the CC areas were smaller in subjects with subjective gait difficulty. The correlations remained significant after correction for ARWMC grade. In conclusion, CC atrophy was independently associated with impaired global cognitive and motor function in subjects with ARWMC.
胼胝体（CC）是连接大脑半球的主要神经束，但人们对CC萎缩的临床意义了解甚少。这项研究的目的是调查患有年龄相关性白质改变（ARWMC）的受试者中CC萎缩与临床及功能之间的关联。在来自脑白质疏松症与残疾（LADIS）研究的569名患有ARWMC的老年受试者中，在标准化的矢状面磁共振成像（MRI）切片上对CC进行分割，并将其细分为五个区域。分析了CC各区域与主观记忆主诉、简易精神状态检查表（MMSE）评分、抑郁病史、老年抑郁量表（GDS）评分、主观步态困难、跌倒史、步行速度以及简短体能状况量表（SPPB）总分之间的相关性。确定了CC萎缩与MMSE、SPPB和步行速度之间存在显著相关性，并且主观步态困难的受试者中CC区域较小。在校正ARWMC分级后，这些相关性仍然显著。总之，在患有ARWMC的受试者中，CC萎缩与整体认知和运动功能受损独立相关。
