Doss J D, McCabe C W
Med Instrum. 1976 Jan-Feb;10(1):16-21.
Increasing evidence of the beneficial effects of hyperthermia in the treatment of tumors, particularly when combined with radiation therapy or chemotherapy, has created the need for practical methods of localizing heat in arbitrary tissue volumes. Heating superficial transplanted animal tumors in hot-water baths has been of considerable importance in research, but the method has very limited clinical application. Microwave diathermy and ultrasound diathermy are capable of greater penetration than external conduction heating, but are also generally limited to the heating of superficial tissue volumes. A more direct method for localized tissue heating is proposed: localized electric current fields produced with carefully specified electrode configurations. This technique, although often quite invasive, offers the possibility of heat localization in almost any treatment volume specified by the therapist. Variations in electrical and thermal properties of tissues can be exploited to improve the architecture of the treatment plan. Several electrode configurations are illustrated. Limitations of the technique are discussed.
越来越多的证据表明热疗在肿瘤治疗中具有有益效果，特别是与放射治疗或化疗联合使用时，这就需要有实用的方法来在任意组织体积中定位热量。在热水浴中加热浅表移植动物肿瘤在研究中具有相当重要的意义，但该方法的临床应用非常有限。微波透热疗法和超声透热疗法比外部传导加热能够实现更大的穿透深度，但通常也仅限于浅表组织体积的加热。本文提出了一种更直接的局部组织加热方法：通过精心设计的电极配置产生局部电流场。该技术虽然通常具有较强的侵入性，但为治疗师指定的几乎任何治疗体积中的热量定位提供了可能性。可以利用组织电学和热学特性的差异来优化治疗计划的设计。文中展示了几种电极配置。同时也讨论了该技术的局限性。
