Liubashina O A
I. P. Pavlov Institute of Physiology of the Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6, Russia.
Ross Fiziol Zh Im I M Sechenova. 2002 Oct;88(10):1343-55.
Mechanisms of the amygdala central nucleus (CNA) influence on gastric motor reflex activity were studied in electrophysiological and neuroanatomical experiments in Wistar rats. In the anaesthetized animals, electrical stimulation of the CNA affected spontaneous gastric motility and caused inhibitory as well as excitatory changes of vagus-induced gastric relaxation. The most significant and mainly inhibitory effects were observed under the stimulation of the medial CNA. Microinjection of the anterograde tracer Phaseolus vulgaris-leucoagglutimn (PHA-L) into the different divisions of the CNA revealed direct projections from its dorso-medial portion to the gastric related area of the dorsal vagal complex. Electrical stimulation of this amygdaloid area was found to change activity of the bulbar gastric related neurons. Inhibitory and excitatory changes of their vagus-induced responses under the amigdala stimulation were manifested as a general modulation of all phases of the reaction or a selective modulation of some of them. These mechanisms may underlie the amygdalo-fugal modulation of gastric motor reflex activity.
在对Wistar大鼠进行的电生理和神经解剖学实验中，研究了杏仁核中央核（CNA）对胃运动反射活动的影响机制。在麻醉动物中，电刺激CNA会影响胃的自发运动，并引起迷走神经诱导的胃舒张的抑制性和兴奋性变化。在内侧CNA刺激下观察到最显著且主要为抑制性的效应。将顺行示踪剂菜豆白细胞凝集素（PHA-L）微量注射到CNA的不同区域，发现其背内侧部分向背侧迷走神经复合体的胃相关区域有直接投射。发现电刺激该杏仁核区域会改变延髓胃相关神经元的活动。在杏仁核刺激下，它们的迷走神经诱导反应的抑制性和兴奋性变化表现为反应所有阶段的总体调节或其中一些阶段的选择性调节。这些机制可能是杏仁核-传出神经对胃运动反射活动进行调节的基础。
