Bernard J F, Alden M, Besson J M
Unité de Recherches de Physiopharmacologie du Système Nerveux, INSERM U 161, Paris, France.
J Comp Neurol. 1993 Mar 8;329(2):201-29. doi: 10.1002/cne.903290205.
The organization of the efferent projections from the pontine parabrachial (pPB) area to the amygdala has been studied in the rat by using microinjections of Phaseolus vulgaris leucoagglutinin (PHA-L), a sensitive and selective anterograde axonal marker, into restricted subregions of the pPB area. The results confirmed that the pPB area primarily projected onto the ipsilateral nucleus centralis of the amygdala (Ce), and to a lesser extent onto the ipsilateral posterior basolateral (BLP), anterior basomedial (BMA), and amygdaloid cortical (ACo) nuclei of the amygdala. Substantial projections were also found in the substantia innominata dorsal/ventral portion of the globus pallidus (SId/GPv), substriatal (SStr), and fondus striatal (FStr) regions which continue the amygdala rostrally. The results demonstrated that the projections of the pPB area onto the Ce were topically organized: 1) The region of the pPB area mainly including the medial subnucleus (pPBm), the waist area (pPBwa), and a thin rostral lamina of the ventral lateral subnucleus (pPBvl) projects primarily to the medial portion of the Ce (CeM). Dense projections were also found in the BLP, BMA, and ACo nuclei of the amygdala, and in the SId/GPv, SStr, and FStr rostral areas. 2) The region of the pPB mainly including the rostral portion of the central lateral subnucleus (pPBcl) and the outer-rostral portion of the external lateral subnucleus (pPBel) projects primarily to the lateral portion of the Ce (CeL). 3) The region of the pPB mainly including the dorsolateral subnucleus (pPBdl), the remaining pPBel, and the external medial (pPBem) subnuclei projects primarily to the lateral capsular portion of the Ce (CeLC) and bilaterally to its rostral portion. Dense projections were also found in the regions which extend the CeLC rostrally and in the SId/GPv, SStr, and FStr rostral areas. The possible role of each of the three parabrachio-amygdaloid pathways described is discussed. It was suggested that the pPB-CeM pathway is mainly implicated in gustatory processes; the pPB-CeL pathway is mainly implicated in visceral and chemosensitive processes; and the pPB-CeLC pathway is mainly implicated in respiratory, cardiovascular, and nociceptive processes.
通过将敏感且具有选择性的顺行轴突标记物菜豆白细胞凝集素（PHA-L）微量注射到大鼠脑桥臂旁（pPB）区域的特定亚区域，对从该区域到杏仁核的传出投射组织进行了研究。结果证实，pPB区域主要投射到杏仁核的同侧中央核（Ce），在较小程度上投射到杏仁核的同侧后基底外侧核（BLP）、前基底内侧核（BMA）和杏仁核皮质核（ACo）。在无名质背侧/腹侧苍白球部分（SId/GPv）、纹状体下（SStr）和纹状体底（FStr）区域也发现了大量投射，这些区域在吻侧延续杏仁核。结果表明，pPB区域到Ce的投射是按局部组织的：1）pPB区域主要包括内侧亚核（pPBm）、腰部区域（pPBwa）和腹外侧亚核的薄吻侧层（pPBvl）的区域主要投射到Ce的内侧部分（CeM）。在杏仁核的BLP、BMA和ACo核以及SId/GPv、SStr和FStr吻侧区域也发现了密集投射。2）pPB主要包括中央外侧亚核吻侧部分（pPBcl）和外侧外侧亚核外侧吻侧部分（pPBel）的区域主要投射到Ce的外侧部分（CeL）。3）pPB主要包括背外侧亚核（pPBdl）、其余的pPBel和外侧内侧（pPBem）亚核的区域主要投射到Ce的外侧囊部分（CeLC），并双侧投射到其吻侧部分。在吻侧延续CeLC的区域以及SId/GPv、SStr和FStr吻侧区域也发现了密集投射。讨论了所描述的三条臂旁-杏仁核通路各自可能的作用。有人提出，pPB-CeM通路主要参与味觉过程；pPB-CeL通路主要参与内脏和化学感受过程；pPB-CeLC通路主要参与呼吸、心血管和伤害感受过程。
