肌动蛋白相关蛋白2/3复合体的结构与功能。
Structure and function of the Arp2/3 complex.
作者信息
Pollard Thomas D, Beltzner Christopher C
机构信息
Department of Molecular, Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, CT 06520-8103, USA.
出版信息
Curr Opin Struct Biol. 2002 Dec;12(6):768-74. doi: 10.1016/s0959-440x(02)00396-2.
Abstract
The Arp2/3 complex, a 220 kDa macromolecular assembly comprising two actin-related proteins and five other subunits, plays a key role in cellular motility by initiating the polymerization of new actin filaments. Crystal and cryo-electron microscopic structures of the Arp2/3 complex and branch junctions have clarified extensive biochemical data on the mechanism of this process.
摘要
Arp2/3复合物是一种由两个肌动蛋白相关蛋白和其他五个亚基组成的220 kDa大分子装配体，通过启动新的肌动蛋白丝的聚合在细胞运动中起关键作用。Arp2/3复合物和分支连接的晶体结构及冷冻电子显微镜结构，已经阐明了关于这一过程机制的大量生化数据。
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