整合素和β-螺旋桨的预测结构与实验结构。

Predicted and experimental structures of integrins and beta-propellers.

作者信息

Springer Timothy A

机构信息

Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.

出版信息

Curr Opin Struct Biol. 2002 Dec;12(6):802-13. doi: 10.1016/s0959-440x(02)00384-6.

DOI:10.1016/s0959-440x(02)00384-6

PMID:12504686

Abstract

Integrins and other cell surface receptors have been fertile grounds for structure prediction experiments. Recently determined structures show remarkable successes, especially with beta-propeller domain predictions, and also reveal how ligand binding by integrins is conformationally regulated.

摘要

整合素和其他细胞表面受体一直是结构预测实验的丰富素材。最近确定的结构显示出显著的成功，尤其是在β-螺旋桨结构域预测方面，并且还揭示了整合素如何通过构象调节来结合配体。