Luo Bing-Hao, Springer Timothy A
The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA.
Curr Opin Cell Biol. 2006 Oct;18(5):579-86. doi: 10.1016/j.ceb.2006.08.005. Epub 2006 Aug 14.
Integrins are cell adhesion molecules that play critical roles in development, wound healing, hemostasis, immunity and cancer. Advances in the past two years have shed light on the structural basis for integrin regulation and signaling, especially on how global conformational changes between bent and extended conformations relate to the inter-domain and intra-domain shape shifting that regulates affinity for ligand. The downward movements of the C-terminal helices of the alpha I and beta I domains and the swing-out of the hybrid domain play pivotal roles in integrin conformational signaling. Experiments have also shown that integrins transmit bidirectional signals across the plasma membrane by coupling extracellular conformational change with an unclasping and separation of the alpha and beta transmembrane and cytoplasmic domains.
整合素是细胞黏附分子，在发育、伤口愈合、止血、免疫和癌症中发挥关键作用。过去两年的进展揭示了整合素调节和信号传导的结构基础，特别是弯曲构象和伸展构象之间的整体构象变化如何与调节配体亲和力的结构域间和结构域内形状变化相关。αI和βI结构域的C末端螺旋的向下运动以及杂合结构域的摆动在整合素构象信号传导中起关键作用。实验还表明，整合素通过将细胞外构象变化与α和β跨膜及细胞质结构域的解开和分离相结合，在质膜上传递双向信号。
