Falcão H A, Gould D B
Ann Intern Med. 1975 Aug;83(2):148-54. doi: 10.7326/0003-4819-83-2-148.
In a patient with chronic hepatosplenic schistosomiasis a segmental sclerosing nephropathy led to terminal renal failure. The demonstration of glomerular capillary deposition of immunoglobulin and complement with electron dense deposits and lucent deformities of the glomerular basement membrane and the presence of antischistosome adult worm antibody in serum suggested that this was an example of immune complex nephropathy. Successful renal transplantation followed by niridazole treatment of the schistosomiasis induced a transient relapse of renal dysfunction with proteinuria and a fall in serum complement. The pathogenic schistosomal adult worm antigen was identified by immunofluorescence in the mesangium of the transplant; complement and immunoglobulin were present also in that site.
在一名慢性肝脾血吸虫病患者中，节段性硬化性肾病导致终末期肾衰竭。肾小球毛细血管免疫球蛋白和补体沉积伴电子致密沉积物以及肾小球基底膜透明变形的表现，加上血清中抗血吸虫成虫抗体的存在，提示这是免疫复合物肾病的一个例子。成功进行肾移植后，用硝咪唑治疗血吸虫病引发了肾功能障碍的短暂复发，伴有蛋白尿和血清补体下降。通过免疫荧光在移植肾的系膜中鉴定出致病性血吸虫成虫抗原；补体和免疫球蛋白也存在于该部位。
