循环免疫复合物在实验性肝脾血吸虫病肾小球疾病中的作用。
The role of circulating immune complexes in the glomerular disease of experimental hepatosplenic schistosomiasis.
作者信息
Digeon M, Droz D, Noel L H, Riza J, Rieumailhol C, Bach J F, Santoro F, Capron A
出版信息
Clin Exp Immunol. 1979 Mar;35(3):329-37.
Abstract
The serological and renal changes were studied simultaneously in 115 mice infected with Schistosoma mansoni. IgG and IgM, but not IgA anti-S. mansoni antibodies were detected in the sera, together with circulating immune complexes containing schistosomal antigen. Glomerular mesangial deposits of IgA, IgM and C3 were observed. Despite the strong correlation observed between the occurrence of the circulating immune complexes containing schistosomal antigen and the glomerular deposits, results concerning the behaviour of IgA suggest that portal hypertension and liver damage have a role in the pathogenesis of glomerular lesions.
摘要
对115只感染曼氏血吸虫的小鼠同时进行了血清学和肾脏变化研究。在血清中检测到了IgG和IgM，但未检测到IgA抗曼氏血吸虫抗体，同时还检测到含有血吸虫抗原的循环免疫复合物。观察到肾小球系膜有IgA、IgM和C3沉积。尽管观察到含有血吸虫抗原的循环免疫复合物的出现与肾小球沉积物之间有很强的相关性，但有关IgA行为的结果表明，门静脉高压和肝损伤在肾小球病变的发病机制中起作用。
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