Van-Wendel-de-Joode Berna, Brouwer Derk H, Vermeulen Roel, Van Hemmen Joop J, Heederik Dick, Kromhout Hans
TNO Chemistry, Department of Chemical Exposure Assessment, PO Box 360, 3700 AJ Zeist, The Netherlands.
Ann Occup Hyg. 2003 Jan;47(1):71-87. doi: 10.1093/annhyg/meg012.
This paper describes a new method (DREAM) for structured, semi-quantitative dermal exposure assessment for chemical or biological agents that can be used in occupational hygiene or epidemiology. It is anticipated that DREAM could serve as an initial assessment of dermal exposure, amongst others, resulting in a ranking of tasks and subsequently jobs. DREAM consists of an inventory and evaluation part. Two examples of dermal exposure of workers of a car-construction company show that DREAM characterizes tasks and gives insight into exposure mechanisms, forming a basis for systematic exposure reduction. DREAM supplies estimates for exposure levels on the outside clothing layer as well as on skin, and provides insight into the distribution of dermal exposure over the body. Together with the ranking of tasks and people, this provides information for measurement strategies and helps to determine who, where and what to measure. In addition to dermal exposure assessment, the systematic description of dermal exposure pathways helps to prioritize and determine most adequate measurement strategies and methods. DREAM could be a promising approach for structured, semi-quantitative, dermal exposure assessment.
本文介绍了一种新方法(DREAM),用于对化学或生物制剂进行结构化的半定量皮肤暴露评估,该方法可用于职业卫生或流行病学领域。预计DREAM可作为皮肤暴露的初步评估方法,除其他用途外,还可对任务进行排序,进而对工作进行排序。DREAM由一个清单和评估部分组成。一家汽车制造公司工人皮肤暴露的两个例子表明,DREAM能够对任务进行特征描述,并深入了解暴露机制,从而为系统地减少暴露奠定基础。DREAM可提供外层衣物以及皮肤上暴露水平的估计值,并能深入了解皮肤暴露在身体上的分布情况。结合任务和人员的排序,这可为测量策略提供信息,并有助于确定测量对象、测量地点和测量内容。除了皮肤暴露评估外,对皮肤暴露途径的系统描述有助于确定优先顺序,并确定最适当的测量策略和方法。DREAM可能是一种用于结构化半定量皮肤暴露评估的有前景的方法。