昼夜节律起搏器网络。

A web of circadian pacemakers.

作者信息

Schibler Ueli, Sassone-Corsi Paolo

机构信息

Department of Molecular Biology, NCCR Frontiers in Genetics, Sciences II, University of Geneva, Switzerland.

出版信息

Cell. 2002 Dec 27;111(7):919-22. doi: 10.1016/s0092-8674(02)01225-4.

DOI:10.1016/s0092-8674(02)01225-4

PMID:12507418

Abstract

The mammalian circadian timing system is composed of almost as many individual clocks as there are cells. These countless oscillators have to be synchronized by a central pacemaker to coordinate temporal physiology and behavior. Recently, there has been some progress in understanding the relationship and communication mechanisms between central and peripheral clocks.

摘要

哺乳动物的昼夜节律计时系统几乎是由与细胞数量一样多的独立时钟组成的。这些无数的振荡器必须由一个中央起搏器进行同步，以协调时间生理学和行为。最近，在理解中央时钟和外周时钟之间的关系及通信机制方面取得了一些进展。