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Prognostic value of baseline human immunodeficiency virus type 1 DNA measurement for disease progression in patients receiving nucleoside therapy.

作者信息

Tierney Camlin, Lathey Janet L, Christopherson Cindy, Bettendorf Daniel M, D'Aquila Richard T, Hammer Scott M, Katzenstein David A

机构信息

Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

出版信息

J Infect Dis. 2003 Jan 1;187(1):144-8. doi: 10.1086/345870. Epub 2002 Dec 13.

DOI:10.1086/345870
PMID:12508159
Abstract

Human immunodeficiency virus (HIV) type 1 DNA assay data were obtained at baseline from 111 HIV-1-positive subjects who were treated with nucleosides. Higher baseline DNA level, HIV-1 RNA level, and infectious titer were comparably associated with an increased hazard of disease progression (each P<.03). Only DNA level was significantly associated with survival (adjusted hazard ratio for 1 log(10) higher level, 3.99; 95% confidence interval, 1.44-11.09; P=.008).

摘要

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