Rezkalla Shereif H, Hayes John J, Curtis Brian R, Aster Richard H
Department of Cardiology, Marshfield Clinic, Marshfield, Wisconsin 54449, USA.
Catheter Cardiovasc Interv. 2003 Jan;58(1):76-9. doi: 10.1002/ccd.10392.
A 61-year-old woman presented with acute coronary syndrome and was given heparin and eptifibatide in conjunction with coronary angioplasty. Shortly thereafter she became profoundly thrombocytopenic (platelets 2.0 x 10(9)/L) and developed severe refractory hypotension. Heparin-induced antibodies were not detected, but the patient developed strong eptifibatide-dependent antibodies specific for platelets that appear to explain both the thrombocytopenia and the hypotensive episode.
一名61岁女性因急性冠状动脉综合征就诊，在接受冠状动脉血管成形术的同时给予肝素和依替巴肽治疗。此后不久，她出现严重血小板减少（血小板计数为2.0×10⁹/L），并出现严重的难治性低血压。未检测到肝素诱导的抗体，但患者产生了针对血小板的强效依替巴肽依赖性抗体，这似乎可以解释血小板减少症和低血压发作。
