Caron Cécile, Col Edwige, Khochbin Saadi
Laboratoire de Biologie Moléculaire et Cellulaire de la Différenciation--Equipe chromatine et expression des gènes, Institut Albert Bonniot, France.
Bioessays. 2003 Jan;25(1):58-65. doi: 10.1002/bies.10202.
It is becoming clear that the post-translational modification of histone and non-histone proteins by acetylation is part of an important cellular signaling process controlling a wide variety of functions in both the nucleus and the cytoplasm. Recent investigations designate this signaling pathway as one of the primary targets of viral proteins after infection. Indeed, specific viral proteins have acquired the capacity to interact with cellular acetyltransferases (HATs) and deacetylases (HDACs) and consequently to disrupt normal acetylation signaling pathways, thereby affecting viral and cellular gene expression. Here we review the targeting of cellular HATs and HDACs by viral proteins and highlight different strategies adopted by viruses to control cellular acetylation signaling and to accomplish their life cycle.
越来越明显的是，组蛋白和非组蛋白通过乙酰化进行的翻译后修饰是细胞重要信号传导过程的一部分，该过程控制着细胞核和细胞质中的多种功能。最近的研究表明，这条信号通路是病毒感染后病毒蛋白的主要作用靶点之一。实际上，特定的病毒蛋白已经具备了与细胞乙酰转移酶（HATs）和脱乙酰酶（HDACs）相互作用并进而破坏正常乙酰化信号通路的能力，从而影响病毒和细胞基因表达。在此，我们综述病毒蛋白对细胞HATs和HDACs的靶向作用，并着重介绍病毒为控制细胞乙酰化信号传导及完成其生命周期所采用的不同策略。
