美国按出生体重/胎龄划分的新生儿死亡率:1995 - 1997年白人、西班牙裔和黑人的死亡率
US birth weight/gestational age-specific neonatal mortality: 1995-1997 rates for whites, hispanics, and blacks.
作者信息
Alexander Greg R, Kogan Michael, Bader Deren, Carlo Wally, Allen Marilee, Mor Joanne
机构信息
Department of Maternal and Child Health, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294-0022, USA.
出版信息
Pediatrics. 2003 Jan;111(1):e61-6. doi: 10.1542/peds.111.1.e61.
OBJECTIVE
In recent years, gains in neonatal survival have been most evident among very low birth weight, preterm, and low birth weight (LBW) infants. Most of the improvement in neonatal survival since the early 1980s seems to be the consequence of decreasing birth weight-specific mortality rates, which occurred during a period of increasing preterm and LBW rates. Although the decline in neonatal mortality has been widely publicized in the United States, research suggests that clinicians may still underestimate the chances of survival of an infant who is born too early or too small and may overestimate the eventuality of serious disability. So that clinicians may have current and needed ethnic- and race-specific estimates of the "chances" of early survival for newborn infants, we examined birth weight/gestational age-specific neonatal mortality rates for the 3 largest ethnic/racial groups in the United States: non-Hispanic whites, Hispanics, and non-Hispanic blacks. Marked racial variation in birth weight and gestational age-specific mortality has long been recognized, and growing concerns have been raised about ongoing and increasing racial disparities in pregnancy outcomes. Our purpose for this investigation was to provide an up-to-date national reference for birth weight/gestational age-specific neonatal mortality rates for use by clinicians in care decision making and discussions with parents.
METHODS
The National Center for Health Statistics linked live birth-infant death cohort files for 1995-1997 were used for this study. Singleton live births to US resident mothers with a reported maternal ethnicity/race of non-Hispanic white, non-Hispanic black, or Hispanic (n = 10 610 715) were selected for analysis. Birth weight/gestational age-specific neonatal mortality rates were calculated using 250 g/2-week intervals for each ethnic/racial group.
RESULTS
The overall neonatal mortality rates for whites, Hispanics, and blacks were 3.24, 3.45, and 8.16 neonatal deaths per 1000 live births, and the proportion of births <28 weeks was 0.35%, 0.45%, and 1.39%, respectively. Newborns who weighed <1500 g comprised <2.5% of all births in each racial/ethnic group but accounted for >50% of neonatal deaths. For whites, Hispanics, and blacks, >50% of newborns 24 to 25 weeks of gestational age survived. For most combinations of birth weights <3500 g and gestational ages of <37 weeks, the neonatal mortality rate was lowest among blacks, compared with whites or Hispanics. At these same gestational age/birth weight combinations, Hispanics have slightly lower mortality rates than whites. For combinations of birth weights >3500 g and gestational ages of 37 to 41 weeks, Hispanics had the lowest neonatal mortality rate. In these birth weight/gestational age combinations, where approximately two thirds of births occur, blacks had the highest neonatal mortality rate.
CONCLUSIONS
Compared with earlier reports, these data suggest that a substantial improvement in birth weight/gestational age-specific neonatal mortality has occurred in the United States. Regardless of ethnicity/race, the risk of a neonatal death does not exceed 50% (the suggested definition for the limit of viability), except for birth weights below 500 g and gestational ages <24 weeks. Notwithstanding, ethnic/racial variations in neonatal mortality rates continue to persist, both in overall rates and within birth weight/gestational age categories. Blacks continue to have higher proportions for preterm and LBW births, compared with either whites or Hispanics. At the same time, blacks experience lower risks of neonatal mortality for preterm and LBW infants, while having higher risks of mortality among term, postterm, normal birth weight, and macrosomic births.
目的
近年来,极低出生体重、早产和低出生体重(LBW)婴儿的新生儿存活率有了显著提高。自20世纪80年代初以来,新生儿存活率的大部分改善似乎是出生体重特异性死亡率下降的结果,而这一时期早产和低出生体重率却在上升。尽管美国新生儿死亡率的下降已得到广泛宣传,但研究表明,临床医生可能仍然低估了过早或过小出生婴儿的存活机会,并且可能高估了严重残疾的可能性。为了使临床医生能够获得当前所需的针对不同种族和民族的新生儿早期存活“机会”的估计,我们研究了美国最大的3个种族/民族群体:非西班牙裔白人、西班牙裔和非西班牙裔黑人的出生体重/胎龄特异性新生儿死亡率。出生体重和胎龄特异性死亡率存在明显的种族差异,人们对妊娠结局中持续存在且不断扩大的种族差异越来越担忧。我们此次调查的目的是提供一份最新的全国性出生体重/胎龄特异性新生儿死亡率参考资料,供临床医生在护理决策和与家长讨论时使用。
方法
本研究使用了国家卫生统计中心1995 - 1997年的活产 - 婴儿死亡队列链接文件。选择向美国居民母亲报告的产妇种族/民族为非西班牙裔白人、非西班牙裔黑人或西班牙裔的单胎活产(n = 10610715)进行分析。每个种族/民族群体以250克/2周的间隔计算出生体重/胎龄特异性新生儿死亡率。
结果
白人、西班牙裔和黑人的总体新生儿死亡率分别为每1000例活产中有3.24、3.45和8.16例新生儿死亡,孕周<28周的出生比例分别为0.35%、0.45%和1.39%。体重<1500克的新生儿在每个种族/民族群体的所有出生中占比均<2.5%,但却占新生儿死亡的>50%。对于白人、西班牙裔和黑人,胎龄24至25周的新生儿中>50%存活。对于大多数体重<3500克且胎龄<37周的组合,与白人或西班牙裔相比,黑人的新生儿死亡率最低。在这些相同的胎龄/出生体重组合中,西班牙裔的死亡率略低于白人。对于体重>3500克且胎龄为37至41周的组合,西班牙裔的新生儿死亡率最低。在这些出生体重/胎龄组合中(约三分之二的出生发生在此范围内),黑人的新生儿死亡率最高。
结论
与早期报告相比,这些数据表明美国出生体重/胎龄特异性新生儿死亡率有了实质性改善。无论种族/民族如何,除了出生体重低于500克和胎龄<24周外,新生儿死亡风险不超过50%(这是建议的生存极限定义)。尽管如此,新生儿死亡率的种族/民族差异在总体率以及出生体重/胎龄类别中仍然持续存在。与白人或西班牙裔相比,黑人早产和低出生体重的比例仍然更高。同时,黑人早产和低出生体重婴儿的新生儿死亡风险较低,而足月、过期产、正常出生体重和巨大儿出生的死亡风险较高。