Harned Andrew M, Mukherjee Shubhasish, Flynn Daniel L, Hanson Paul R
Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7582, USA.
Org Lett. 2003 Jan 9;5(1):15-8. doi: 10.1021/ol0270327.
The use of ring-opening metathesis (ROM) oligomers as soluble supports for a multistep reaction sequence is described. A Mitsunobu reaction followed by an in situ ROMP-mediated phase-trafficking purification is utilized to generate soluble ROM oligomers that are isolated via precipitation with methanol. Once formed, the ROM oligomers serve as soluble supports for further solution-phase reactions, including a ring-closing metathesis. After each step, the support-bound products are isolated by precipitation with a suitable solvent. [reaction--see text]
本文描述了使用开环复分解（ROM）低聚物作为多步反应序列的可溶性载体。利用Mitsunobu反应，随后进行原位ROMP介导的相转移纯化，以生成通过用甲醇沉淀分离的可溶性ROM低聚物。一旦形成，ROM低聚物就作为进一步溶液相反应（包括闭环复分解）的可溶性载体。每一步之后，通过用合适的溶剂沉淀来分离与载体结合的产物。[反应——见正文]
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