一种制备功能化Janus树枝状大分子的液相方法：用于有机合成的新型可溶性载体。

A liquid-phase approach to functionalized Janus dendrimers: novel soluble supports for organic synthesis.

作者信息

Feng Yu, He Yan-Mei, Zhao Li-Wen, Huang Yi-Yong, Fan Qing-Hua

机构信息

Beijing National Laboratory for Molecular Sciences, Center for Chemical Biology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China.

出版信息

Org Lett. 2007 Jun 7;9(12):2261-4. doi: 10.1021/ol0705393. Epub 2007 May 17.

DOI:10.1021/ol0705393

PMID:17506573

Abstract

A new kind of functionalized Janus dendrimer has been synthesized via a liquid-phase approach, which could easily be purified using a simple precipitation method without the need for chromatographic separation. Their use for liquid-phase organic synthesis has been achieved in the Pd-catalyzed Suzuki coupling reactions, giving biaryl products in excellent yields after cleavage.

摘要

一种新型的功能化Janus树枝状大分子已通过液相方法合成，它可以使用简单的沉淀法轻松纯化，无需色谱分离。它们在钯催化的铃木偶联反应中用于液相有机合成，裂解后能以优异的产率得到联芳基产物。