Zhu Fang, Ji Linong, Luo Bin
Department of Endocrinology and Metabolism, People's Hospital of Peking University, Beijing 100044, China.
Zhonghua Yi Xue Za Zhi. 2002 Nov 10;82(21):1473-5.
To investigate the relationship between the polymorphism of site rs228648 in urotensin II gene and the genetic susceptibility to type 2 diabetes in Han people.
Genotyping was conducted to investigate the polymorphism of site rs228648 (G-A) in urotensin II gene among 166 unrelated type 2 diabetic subjects (case group 1), 87 probands from 87 families of type 2 diabetics (case group 2), and 121 non-diabetic normal controls (control group).
Urotensin II gene may contribute to the genetic susceptibility to type 2 diabetes in Han population.
探讨尾加压素II基因rs228648位点多态性与汉族人群2型糖尿病遗传易感性的关系。
对166例无亲缘关系的2型糖尿病患者（病例组1）、87个2型糖尿病家系中的87名先证者（病例组2）和121名非糖尿病正常对照者（对照组）进行基因分型，以研究尾加压素II基因rs228648（G→A）位点的多态性。
1）rs228648位点“G”等位基因频率在病例组1和病例组2中分别为62.3%和75.3%，显著高于对照组（50.4%，P = 0.004，P < 0.001）。2）rs228648的G/G基因型频率在病例组1和病例组2中分别为35%和53%，显著高于对照组（24%，P < 0.05，P < 0.01）。经性别、年龄和BMI校正后，病例组1的比值比为1.86，P = 0.041；病例组2的比值比为4.03，P < 0.001。
尾加压素II基因可能与汉族人群2型糖尿病的遗传易感性有关。
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