[尾加压素II基因在中国人群2型糖尿病遗传易感性中的作用]

[The role of urotensin II gene in the genetic susceptibility to type 2 diabetes in Chinese population].

作者信息

Zhu Fang, Ji Linong, Luo Bin

机构信息

Department of Endocrinology and Metabolism, People's Hospital of Peking University, Beijing 100044, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2002 Nov 10;82(21):1473-5.

PMID:12509909

Abstract

OBJECTIVE

To investigate the relationship between the polymorphism of site rs228648 in urotensin II gene and the genetic susceptibility to type 2 diabetes in Han people.

METHODS

Genotyping was conducted to investigate the polymorphism of site rs228648 (G-A) in urotensin II gene among 166 unrelated type 2 diabetic subjects (case group 1), 87 probands from 87 families of type 2 diabetics (case group 2), and 121 non-diabetic normal controls (control group).

RESULTS

The frequency of "G" allele of site rs228648 was 62.3% and 75.3% in case group 1 and case group 2 respectively, significantly higher than that in the control group (50.4%, P = 0.004 and P < 0.001). 2) The frequency of G/G genotype of rs228648 was 35% and 53% in case group 1 and case group 2 respectively, significantly higher than that in the control group (24%, P < 0.05 and P < 0.01). The odds ratio was 1.86, P = 0.041 in the case group 1 and 4.03, P < 0.001 in the case control 2 after adjustment by sex, age and BMI.

CONCLUSION

Urotensin II gene may contribute to the genetic susceptibility to type 2 diabetes in Han population.

摘要

目的

探讨尾加压素II基因rs228648位点多态性与汉族人群2型糖尿病遗传易感性的关系。

方法

对166例无亲缘关系的2型糖尿病患者（病例组1）、87个2型糖尿病家系中的87名先证者（病例组2）和121名非糖尿病正常对照者（对照组）进行基因分型，以研究尾加压素II基因rs228648（G→A）位点的多态性。

结果

1）rs228648位点“G”等位基因频率在病例组1和病例组2中分别为62.3%和75.3%，显著高于对照组（50.4%，P = 0.004，P < 0.001）。2）rs228648的G/G基因型频率在病例组1和病例组2中分别为35%和53%，显著高于对照组（24%，P < 0.05，P < 0.01）。经性别、年龄和BMI校正后，病例组1的比值比为1.86，P = 0.041；病例组2的比值比为4.03，P < 0.001。