Wu Xue-ji, Qin Lei, Zhou Jin-yi, Cheng Jin-luo, Shen Mo-yu, Wang Jin-song, Zhou Ling
Department of Epidemiology and Statistics, Nanjing Medical University, Nanjing, Jiangsu, 210029 PR China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Dec;24(6):656-9.
To investigate the association between a polymorphism (rs228648) of urotensin II (UT-II) gene and type 2 diabetes in pedigrees.
Patients and controls with/without familial history were enrolled in the same place.
Carriers with AG or AA genotype from pedigrees had higher disease risk than those with GG genotype (OR=1.98, 95% CI:1.19-3.29,OR=2.46,95% CI:1.39-4.34), the frequency of A allele was higher in the patients from pedigrees than inner controls and patients who had no familial history (P=0.01). The frequency of A allele was higher in the inner controls than outer ones (P=0.001). The insulin resistance index, insulin sensitivity index and pancreatic secretion index of inner controls with AG genotype were higher than those with GG genotype (All P < 0.05).
This polymorphism of UT-II gene might be a risk to type 2 diabetes, the insulin function of people from pedigrees is associated with the mutation.
研究尿紧张素II（UT-II）基因多态性（rs228648）与家系2型糖尿病之间的关联。
在同一地点招募有/无家族史的患者及对照。
家系中AG或AA基因型携带者的患病风险高于GG基因型携带者（OR=1.98，95%CI：1.19-3.29，OR=2.46，95%CI：1.39-4.34），家系患者中A等位基因频率高于内部对照及无家族史患者（P=0.01）。内部对照中A等位基因频率高于外部对照（P=0.001）。AG基因型内部对照的胰岛素抵抗指数、胰岛素敏感指数及胰腺分泌指数高于GG基因型内部对照（均P<0.05）。
UT-II基因的这种多态性可能是2型糖尿病的一个风险因素，家系人群的胰岛素功能与该突变有关。
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