Trost Barry M, Terrell Lamont R
Department of Chemistry, Stanford University, California 94305-5080, USA.
J Am Chem Soc. 2003 Jan 15;125(2):338-9. doi: 10.1021/ja028782e.
The Mannich reaction is one of the most widely utilized chemical transformations for the construction of nitrogen-containing compounds. With the increasing occurrence of nitrogen in drugs and natural products, highly asymmetric variants of the Mannich reaction are desirable. In this communication, we report the application of our dinuclear zinc catalyst to a highly asymmetric Mannich-type reaction to generate syn 1,2-amino alcohols.
曼尼希反应是构建含氮化合物时应用最为广泛的化学转化反应之一。随着氮元素在药物和天然产物中出现频率的增加，曼尼希反应的高度不对称变体备受期待。在本通讯中，我们报道了双核锌催化剂在高度不对称曼尼希型反应中的应用，以生成顺式1,2-氨基醇。
