Levin D L, Muster A J, Pachman L M, Wessel H U, Paul M H, Koshaba J
Chest. 1975 Aug;68(2):166-71. doi: 10.1378/chest.68.2.166.
Previous reports of cor pulmonale due to upper airway obstruction have not noted that chronic hypoxemia due to alveolar hypoventilation can lead to left as well as right ventricular failure in these patients. We found elevated left ventricular end-diastolic pressure in four of five patients. Although these patients have frequent respiratory infections, no investigation of their immune status has previously been reported. We performed such investigations but could not demonstrate an immunologic deficiency. Although nine of 44 patients previously reported were mentally retarded, no psychometric data were available. We studied five patients but could not determine the role of mental subnormality in this syndrome. Diagnosis of this syndrome should be suspected when clinical and roentgenographic findings of biventricular heart failure are associated with right ventricular hypertrophy on electrocardiogram. The diagnosis of alveolar hypoventilation is confirmed by blood gas findings and examination of the upper airways. Surgical removal of obstructive tissue reverses the cardiac involvement.
以往关于上气道梗阻所致肺心病的报道未指出，肺泡通气不足引起的慢性低氧血症可导致这些患者发生左心室和右心室衰竭。我们发现五名患者中有四名左心室舒张末期压力升高。尽管这些患者频繁发生呼吸道感染，但此前尚无关于其免疫状态的调查报道。我们进行了此类调查，但未发现免疫缺陷。尽管先前报道的44名患者中有9名智力发育迟缓，但没有心理测量数据。我们研究了五名患者，但无法确定智力低下在该综合征中的作用。当双心室心力衰竭的临床和X线表现与心电图显示的右心室肥厚相关时，应怀疑该综合征的诊断。肺泡通气不足的诊断通过血气检查结果和上呼吸道检查来证实。手术切除阻塞性组织可逆转心脏病变。
