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急性缺氧对大鼠脑代谢及神经功能相关酶的影响。

Effect of acute hypoxia on the enzymes involved in the metabolic and nervous functioning of rat brain.

作者信息

Purshottam T, Ghosh N C

出版信息

Environ Physiol Biochem. 1975;5(2):73-7.

PMID:125197
Abstract

Rats were exposed to a simulated altitude of 25,000 ft for 4 h in a decompression chamber, and the activity of some tissue enzymes estimated. Succinate dehydrogenase activity was significantly decreased and cholinesterase activity significantly elevated in the brain homogenates of the hypoxic rats, succinic dehydrogenase activity was significantly increased. There was no change in the activity of Mg+2-ATPase and Na+-K+-ATPase in the microsomal fractions of liver or brain homogenates of the hypoxic animals.

摘要

将大鼠置于减压舱中,暴露于模拟海拔25000英尺的环境下4小时,然后评估一些组织酶的活性。缺氧大鼠脑匀浆中的琥珀酸脱氢酶活性显著降低,胆碱酯酶活性显著升高,琥珀酸脱氢酶活性显著增加。缺氧动物肝脏或脑匀浆微粒体部分中Mg+2 - ATP酶和Na+-K+-ATP酶的活性没有变化。

相似文献

1
Effect of acute hypoxia on the enzymes involved in the metabolic and nervous functioning of rat brain.急性缺氧对大鼠脑代谢及神经功能相关酶的影响。
Environ Physiol Biochem. 1975;5(2):73-7.
2
Activity of microsomal Na + -K + -ATPase in different tissues of rats under varying levels of acute hypoxia.急性缺氧不同水平下大鼠不同组织微粒体钠钾ATP酶的活性
Indian J Exp Biol. 1972 Jul;10(4):310-2.
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Effect of acetazolamide (Diamox) at different dose levels on survival time of rats under acute hypoxia and on Na + -K + -ATP-ase activity of rat tissue microsomes.不同剂量水平的乙酰唑胺(醋氮酰胺)对大鼠急性缺氧存活时间及大鼠组织微粒体钠钾ATP酶活性的影响。
Aerosp Med. 1972 Jun;43(6):610-3.
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[The effect of taurine on the activity of transport ATPases and of energy metabolism enzymes in different tissues of rats with acute hypoxic hypoxia].[牛磺酸对急性低氧性缺氧大鼠不同组织中转运ATP酶及能量代谢酶活性的影响]
Ukr Biokhim Zh (1978). 1992 Nov-Dec;64(6):43-8.
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Effect of altitude hypoxia on ATPase activity in the brain of rats of different ages.
Physiol Bohemoslov. 1979;28(2):129-35.
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[Histochemical picture of lactate dehydrogenase, succinic dehydrogenase and glutamate dehydrogenase in the central nervous system of rats exposed repeatedly for a prolonge period to aerogenic hypoxia during early ontogenesis (author's transl)].[早期个体发育期间长期反复暴露于气生性缺氧环境的大鼠中枢神经系统中乳酸脱氢酶、琥珀酸脱氢酶和谷氨酸脱氢酶的组织化学图像(作者译)]
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[Dynamics of changes in the cerebral and erythrocyte ATPase activity of rats with hypoxic hypoxia].[低氧性缺氧大鼠脑和红细胞ATP酶活性的变化动态]
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[Changes in the ATPase activity of the brain and erythrocytes in hypoxia].[缺氧时脑和红细胞中ATP酶活性的变化]
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[Change in brain ATPase activity during altitude adaptation].[高原适应过程中脑ATP酶活性的变化]
Patol Fiziol Eksp Ter. 1979 Jan-Feb(1):17-20.
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[Monoamine oxidase and respiratory chain enzymatic activity in acute hypoxia].[急性缺氧时单胺氧化酶与呼吸链酶活性]
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2
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J Bioenerg Biomembr. 1990 Feb;22(1):61-80. doi: 10.1007/BF00762846.