豚鼠氰化物中毒的羟钴胺素治疗
Hydroxocobalamin therapy of cyanide intoxication in guinea pigs.
作者信息
Posner M A, Tobey R E, McElroy H
出版信息
Anesthesiology. 1976 Feb;44(2):157-60. doi: 10.1097/00000542-197602000-00017.
Abstract
The efficacy of hydroxocobalamin (vitamin B12a) as a specific, nontoxic antidote in acute cyanide poisoning was tested. Guinea pigs receiving lethal intravenous NaCN injections were treated with either vitamin B12a or saline solution. There was a statistically significant antidotal effect of the vitamin. No toxic effect was observed with large doses of the vitamin.
摘要
对羟基钴胺素（维生素B12a）作为急性氰化物中毒的一种特效、无毒解毒剂的功效进行了测试。接受致死剂量静脉注射氰化钠的豚鼠，分别用维生素B12a或盐溶液进行治疗。该维生素具有统计学上显著的解毒作用。大剂量使用该维生素未观察到毒性作用。
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