对组织学确诊的与多发性肌炎/皮肌炎相关的间质性肺炎发病情况的时间顺序评估。

Chronological evaluation of the onset of histologically confirmed interstitial pneumonia associated with polymyositis/dermatomyositis.

作者信息

Yang Yu, Fujita Jiro, Tokuda Michiaki, Bandoh Shuji, Ishida Toshihiko

机构信息

First Department of Internal Medicine, Kagawa Medical University, Kita-gun, Kagawa.

出版信息

Intern Med. 2002 Dec;41(12):1135-41. doi: 10.2169/internalmedicine.41.1135.

DOI:10.2169/internalmedicine.41.1135

PMID:12521202

Abstract

OBJECTIVE

The present study was designed to determine the chronological sequence of interstitial pneumonia, skin involvement, and muscle involvement associated with polymyositis/dermatomyositis (PM/DM).

METHODS

We examined our own cases of histologically confirmed interstitial pneumonia associated with PM/DM. In addition, a review of the literature was done to evaluate other cases of histologically confirmed interstitial pneumonia associated with PM/DM. Lung involvement was the first clinical symptom for all of our 8 patients.

RESULTS

Including the literature review and our 8 cases, there were 94 patients with PM/DM in whom interstitial pneumonia was histologically confirmed (36 PM, 50 DM, and 8 amyopathic DM). Chronological evaluation between the diagnosis of PM/DM and lung involvement demonstrated that most lung involvement occurred just before or just after the diagnosis of PM/DM. Interstitial pneumonia was preceded in 35 of 87 evaluable patients [21 cases with PM (61.8%), 14 cases with DM and amyopathic DM (40.2%)]. In 60 of 87 evaluable patients (69.0%), lung involvement occurred as a clinical manifestation at the diagnosis of PM/DM.

CONCLUSION

The present data demonstrate that interstitial pneumonia was frequently the initial onset in patients with PM/DM.

摘要

目的

本研究旨在确定与多发性肌炎/皮肌炎（PM/DM）相关的间质性肺炎、皮肤受累及肌肉受累的时间顺序。

方法

我们检查了自身经组织学确诊的与PM/DM相关的间质性肺炎病例。此外，还对文献进行了回顾，以评估其他经组织学确诊的与PM/DM相关的间质性肺炎病例。肺部受累是我们所有8例患者的首发临床症状。

结果

包括文献回顾及我们的8例病例，共有94例PM/DM患者经组织学确诊为间质性肺炎（36例多发性肌炎、50例皮肌炎和8例无肌病性皮肌炎）。对PM/DM诊断与肺部受累之间的时间评估表明，大多数肺部受累发生在PM/DM诊断之前或之后不久。在87例可评估患者中，35例（21例多发性肌炎患者占61.8%，14例皮肌炎和无肌病性皮肌炎患者占40.2%）间质性肺炎之前有其他症状。在87例可评估患者中，60例（69.0%）肺部受累是在PM/DM诊断时的临床表现。