McDonnell P A, Scott K G-E, Teoh D A, Olson M E, Upcroft J A, Upcroft P, Buret A G
School of Biomolecular and Biomedical Science, Faculty of Science, Griffith University, Kessels Road, Nathan 4111, Qld, Australia.
Vet Parasitol. 2003 Jan 20;111(1):31-46. doi: 10.1016/s0304-4017(02)00349-7.
This study examines the ability of Giardia duodenalis trophozoites, isolated from a wild bird, to colonize the intestinal tracts of companion animals (kittens) and domestic ruminants (lambs). Trophozoites colonized the intestinal tracts of intraduodenally inoculated animals as demonstrated by increasing parasite burdens within the duodenum and jejunum and by fecal passage of cysts within 4 days post-inoculation. The pathogenesis of the trophozoites was further investigated in kittens. In these animals, infection significantly reduced jejunal brush border microvillous length and density, which resulted in a loss of overall epithelial brush border surface area. This injury was associated with the production of diarrhea in four of five infected kittens. These findings indicate that some bird species may carry G. duodenalis that represent a possible health threat to companion animals and livestock. Our results describe the first successful colonization of avian-derived G. duodenalis trophozoites in the small intestines of domestic kittens and lambs.
本研究检测了从一只野生鸟类分离出的十二指肠贾第鞭毛虫滋养体定殖于伴侣动物（小猫）和家养反刍动物（羔羊）肠道的能力。十二指肠内接种动物后，十二指肠和空肠内的寄生虫负荷增加，且接种后4天内粪便中有包囊排出，这表明滋养体定殖于肠道。在小猫中进一步研究了滋养体的发病机制。在这些动物中，感染显著缩短了空肠刷状缘微绒毛的长度和密度，导致上皮刷状缘总面积减少。这种损伤与五只受感染小猫中有四只出现腹泻有关。这些发现表明，一些鸟类可能携带十二指肠贾第鞭毛虫，这对伴侣动物和家畜可能构成健康威胁。我们的结果描述了源自鸟类的十二指肠贾第鞭毛虫滋养体首次成功定殖于家养小猫和羔羊的小肠。
