川芎-赤芍配比犬体内芍药苷药代动力学研究

[Effects of chuanxiong-chishao dispensing ratio on the pharmacokinetics of paeoniflorin in the canine].

作者信息

Zhang Z, Yan Y F, Chen K

机构信息

Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing 100091, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2000 Nov;25(11):688-91.

PMID:12525076

Abstract

OBJECTIVE

To explore the effects of dispensing ratio of Chinese herbs on the pharmacokinetic characteristics of effective components.

METHODS

Paeoniflorin (PF) in serum was determined by RP-HPLC with UV-detector. The concentration-time data were fitted using 3P87 Pharmacokinetic Program, and the pharmacokinetic parameters were compared by t-test.

RESULTS

The concentration-time curves of PF in both groups of Chuanxiong: Chishao 1:2 and 2:1 Xiongshao Pharmaceutics administrated intragastrically fitted open one compartment model. Parameters of Chuanxiong: Chishao 1:2 and 2:1 groups: Ka = 0.0082 +/- 0.0010 and 0.0088 +/- 0.0011(min-1), Ke = 0.0060 +/- 0.0015 and 0.0071 +/- 0.0008(min-1), t1/2Ka = 86.10 +/- 12.38 and 79.11 +/- 18.69(min), t1/2Ke = 119.95 +/- 27.23 and 98.14 +/- 10.82(min), tpeak = 169.16 +/- 21.18 and 149.39 +/- 29.51(min), Cmax = 3845.89 +/- 716.70 and 1635.81 +/- 230.95 (micrograms.L-1) respectively. The pharmacokinetic parameters of the two groups had no statistically significant differences (p > 0.05).

CONCLUSION

Different formulae of Chinese herbs do not always result in changes of pharmacokinetic characteristics of some one component.

摘要

目的

探讨中药配方比例对有效成分药代动力学特征的影响。

方法

采用反相高效液相色谱-紫外检测器法测定血清中芍药苷（PF）含量。用3P87药代动力学程序拟合浓度-时间数据，并用t检验比较药代动力学参数。

结果

川芎：赤芍1:2和2:1芎芍制剂灌胃给药后两组PF的浓度-时间曲线均拟合开放一室模型。川芎：赤芍1:2组和2:1组参数：Ka = 0.0082±0.0010和0.0088±0.0011（min-1），Ke = 0.0060±0.0015和0.0071±0.0008（min-1），t1/2Ka = 86.10±12.38和79.11±18.69（min），t1/2Ke = 119.95±27.23和98.14±10.82（min），tpeak = 169.16±21.18和149.39±29.51（min），Cmax = 3845.89±716.70和1635.81±230.95（μg.L-1）。两组药代动力学参数无统计学差异（p > 0.05）。