枯草芽孢杆菌的LytG是一种新型肽聚糖水解酶：主要活性葡糖胺酶。
LytG of Bacillus subtilis is a novel peptidoglycan hydrolase: the major active glucosaminidase.
作者信息
Horsburgh Gavin J, Atrih Abdelmadjid, Williamson Michael P, Foster Simon J
机构信息
Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, S10 2TN, United Kingdom.
出版信息
Biochemistry. 2003 Jan 21;42(2):257-64. doi: 10.1021/bi020498c.
LytG (YubE) of Bacillus subtilis is a novel 32 kDa autolysin produced during vegetative growth under the control of Esigma(A) RNA polymerase. Muropeptide analysis of vegetative cells of B. subtilis revealed LytG to be the major glucosaminidase responsible for peptidoglycan structural determination during vegetative growth. Overexpression and purification of LytG allowed its biochemical characterization. Despite sequence homology suggesting muramidase activity, LytG is a novel glucosaminidase with exoenzyme activity and may form part of a novel family of autolysins. It is involved in cell division, lysis, and motility on swarm plates.
枯草芽孢杆菌的LytG（YubE）是一种新型的32 kDa自溶素，在营养生长期间由σ（A）RNA聚合酶控制产生。对枯草芽孢杆菌营养细胞的胞壁肽分析表明，LytG是营养生长期间负责肽聚糖结构测定的主要氨基葡萄糖苷酶。LytG的过表达和纯化使其能够进行生化特性分析。尽管序列同源性表明具有溶菌酶活性，但LytG是一种具有外切酶活性的新型氨基葡萄糖苷酶，可能构成一个新型自溶素家族的一部分。它参与细胞分裂、裂解以及在群体平板上的运动。
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