[激素敏感型单纯性肾病综合征患儿外周血单个核细胞呼吸道病毒抗原与其抗体关系的研究]
[A study on the relationship between respiratory tract viruses antigen in peripheral blood mononuclear cells and their antibody from children with steroid-sensitive and simple nephrotic syndrome].
作者信息
Wang Z, Mu L, Tao Y, Yuan L
机构信息
Department of Pediatrics, Second Affiliated Hospital, WCUMS, Chengdu 610041, China.
出版信息
Hua Xi Yi Ke Da Xue Xue Bao. 2001 Dec;32(4):559-61.
OBJECTIVE
To explore whether respiratory tract viruses infection was involved in the pathogenesis of sterioid-senstive and simple nephrotic syndrome(SSSNS).
METHODS
Using APAAP and ELISA, the authors assayed the expression of respiratory tract viruses antigen in peripheral blood mononuclear cells (PBMC) and the production of viruses antibody in serum from 20 cases of children with steroid-sensitive and simple nephrotic syndrome.
RESULTS
The positive rate of viruses in the active stage group of SSSNS children increased (P < 0.05), compared with that in the remission group and the healthy control group. The positive rate of virus detection in SSSNS children was closely related with the quantity of urinary protein(P < 0.05). The positive rate of virus detection in the group with urinary protein > or = 50 mg/(kg.d) was higher than that in the group with urinary protein < 50 mg/(kg.d).
CONCLUSION
The onset of SSSNS may be related to the infection of respiratory tract viruses.
目的
探讨呼吸道病毒感染是否参与激素敏感型单纯性肾病综合征（SSSNS）的发病机制。
方法
作者采用碱性磷酸酶抗碱性磷酸酶法（APAAP）和酶联免疫吸附测定法（ELISA），检测了20例激素敏感型单纯性肾病综合征患儿外周血单个核细胞（PBMC）中呼吸道病毒抗原的表达及血清中病毒抗体的产生。
结果
与缓解期组和健康对照组相比，SSSNS患儿活动期组病毒阳性率升高（P<0.05）。SSSNS患儿病毒检测阳性率与尿蛋白量密切相关（P<0.05）。尿蛋白≥50mg/（kg·d）组病毒检测阳性率高于尿蛋白<50mg/（kg·d）组。
结论
SSSNS的发病可能与呼吸道病毒感染有关。
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