Zhu Xiaofeng, Cooper Richard S
Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, 2160 S. First Ave, Maywood, IL 60153, USA.
Curr Hypertens Rep. 2003 Feb;5(1):40-6. doi: 10.1007/s11906-003-0009-x.
The genes of the renin-angiotensin system (RAS) are important candidates to confer susceptibility to cardiovascular diseases. A large number of association studies between cardiovascular traits and the polymorphisms in RAS have been conducted, although inconsistent results are often reported. The patterns of linkage disequilibrium in RAS genes have also been reported in different populations. However, our understanding of the genetic architecture underlying the RAS is still limited despite rapid progress in empiric studies regarding the patterns of the human genome as a whole. In this review, the linkage disequilibrium among the polymorphisms within the four RAS genes and current association analyses involving the RAS are discussed, as well as some of the gaps of knowledge and possible solutions.
肾素-血管紧张素系统（RAS）的基因是导致心血管疾病易感性的重要候选基因。尽管经常报道结果不一致，但已经进行了大量关于心血管特征与RAS基因多态性之间的关联研究。不同人群中也报道了RAS基因的连锁不平衡模式。然而，尽管在关于整个人类基因组模式的实证研究方面取得了快速进展，但我们对RAS潜在遗传结构的理解仍然有限。在这篇综述中，讨论了四个RAS基因内多态性之间的连锁不平衡以及目前涉及RAS的关联分析，以及一些知识空白和可能的解决方案。
