Affolter Markus, Bellusci Savério, Itoh Nobuyuki, Shilo Benny, Thiery Jean-Paul, Werb Zena
Abteilung Zellbiologie, Biozentrum der Universität Basel, CH-4056, Basel, Switzerland.
Dev Cell. 2003 Jan;4(1):11-8. doi: 10.1016/s1534-5807(02)00410-0.
Branching morphogenesis involves the restructuring of epithelial tissues into complex and organized ramified tubular networks. Early rounds of branching are controlled genetically in a hardwired fashion in many organs, whereas later, branching is stochastic, responding to environmental cues. We discuss this sequential process from formation of an organ anlage and invagination of the epithelium to branch initiation and outgrowth in several model systems including Drosophila trachea and mammalian lung, mammary gland, and kidney.
分支形态发生涉及上皮组织重构成复杂且有组织的分支管状网络。在许多器官中，早期的分支是以一种固定的遗传方式控制的，而后期的分支是随机的，对环境信号作出反应。我们将在包括果蝇气管以及哺乳动物的肺、乳腺和肾脏在内的几个模型系统中，讨论从器官原基的形成、上皮内陷到分支起始和生长的这一连续过程。
