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动态成人气管可塑性驱动果蝇肠道内稳态变化中的干细胞适应性。

Dynamic adult tracheal plasticity drives stem cell adaptation to changes in intestinal homeostasis in Drosophila.

机构信息

Institute of Cancer Sciences-University of Glasgow, Wolfson Wohl Cancer Research Centre, Glasgow, UK.

Cancer Research UK Beatson Institute, Glasgow, UK.

出版信息

Nat Cell Biol. 2021 May;23(5):485-496. doi: 10.1038/s41556-021-00676-z. Epub 2021 May 10.

DOI:10.1038/s41556-021-00676-z
PMID:33972729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7610788/
Abstract

Coordination of stem cell function by local and niche-derived signals is essential to preserve adult tissue homeostasis and organismal health. The vasculature is a prominent component of multiple stem cell niches. However, its role in adult intestinal homeostasis remains largely understudied. Here we uncover a previously unrecognised crosstalk between adult intestinal stem cells in Drosophila and the vasculature-like tracheal system, which is essential for intestinal regeneration. Following damage to the intestinal epithelium, gut-derived reactive oxygen species activate tracheal HIF-1α and bidirectional FGF/FGFR signalling, leading to reversible remodelling of gut-associated terminal tracheal cells and intestinal stem cell proliferation following damage. Unexpectedly, reactive oxygen species-induced adult tracheal plasticity involves downregulation of the tracheal specification factor trachealess (trh) and upregulation of IGF2 messenger RNA-binding protein (IGF2BP2/Imp). Our results reveal an intestine-vasculature inter-organ communication programme that is essential to adapt the stem cell response to the proliferative demands of the intestinal epithelium.

摘要

干细胞功能的协调是通过局部和小生境来源的信号来实现的，这对于维持成人组织内稳态和生物体健康至关重要。脉管系统是多个干细胞小生境的重要组成部分。然而，其在成人肠道内稳态中的作用在很大程度上仍未得到充分研究。在这里，我们揭示了果蝇中成年肠道干细胞与脉管系统样的气管系统之间以前未被识别的相互作用，这对于肠道再生是必不可少的。在肠道上皮损伤后，肠道来源的活性氧激活了气管中的 HIF-1α 和双向 FGF/FGFR 信号，导致肠道相关终末气管细胞的可逆重塑，以及损伤后的肠道干细胞增殖。出乎意料的是，活性氧诱导的成年气管可塑性涉及气管缺失（trh）的下调和 IGF2 信使 RNA 结合蛋白（IGF2BP2/Imp）的上调。我们的结果揭示了一种肠-血管的器官间通讯程序，对于适应干细胞对肠道上皮增殖需求的反应是必不可少的。

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2
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Dev Cell. 2020 Aug 24;54(4):516-528.e7. doi: 10.1016/j.devcel.2020.07.023.
3
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Elife. 2025 Jun 9;13:RP100037. doi: 10.7554/eLife.100037.
4
Expansion of Drosophila haemocytes using a conditional GeneSwitch driver affects larval haemocyte function, but does not modulate adult lifespan or survival after severe infection.利用条件性基因开关驱动因子扩增果蝇血细胞会影响幼虫血细胞功能，但不会调节成年果蝇的寿命或严重感染后的存活率。
J Exp Biol. 2025 May 1;228(9). doi: 10.1242/jeb.249649. Epub 2025 May 6.
5
Communication between organs defines their sex-specific shapes.器官之间的交流决定了它们的性别特异性形状。
Nature. 2024 Jun;630(8016):307-308. doi: 10.1038/d41586-024-01362-4.
6
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Nature. 2024 Jun;630(8016):392-400. doi: 10.1038/s41586-024-07463-4. Epub 2024 May 29.
7
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