一项针对青春期前儿童的大规模甲型肝炎疫苗接种计划的有效性。
Effectiveness of a mass hepatitis A vaccination program in preadolescents.
作者信息
Domínguez Angela, Salleras Lluís, Carmona Glòria, Batalla Juan
机构信息
Department of Health and Social Security, General Directorate of Public Health, Generalitat of Catalonia, Travessera de les Corts, 131-159, 08028, Barcelona, Spain.
出版信息
Vaccine. 2003 Jan 30;21(7-8):698-701. doi: 10.1016/s0264-410x(02)00583-2.
A program of mass hepatitis A+B vaccination in preadolescents in schools was begun in the Catalonia in the last quarter of 1998. This study investigated the impact of the program by comparing the incidence of hepatitis A in vaccinated and unvaccinated cohort. The greatest reduction of the incidence rate of hepatitis A was observed in the 10-14 years age group, from 10.3 per 100000 persons-year in the period 1996-1998 to 1.8 per 100000 persons-year in the period 1999-2001. The global incidence decreased from 6.2 to 2.6 per 100000 persons-year. After analysis of cases occurring in the vaccinated and non vaccinated cohort, the effectiveness of the vaccination program was estimated at 97.0% (95% CI: 78.6-99.6).
1998年最后一个季度，加泰罗尼亚地区启动了一项针对在校青少年的甲型和乙型肝炎大规模疫苗接种计划。本研究通过比较接种疫苗和未接种疫苗队列中甲型肝炎的发病率，调查了该计划的影响。甲型肝炎发病率下降幅度最大的是10至14岁年龄组，从1996 - 1998年期间的每10万人年10.3例降至1999 - 2001年期间的每10万人年1.8例。总体发病率从每10万人年6.2例降至2.6例。在分析接种疫苗和未接种疫苗队列中出现的病例后，估计疫苗接种计划的有效性为97.0%（95%置信区间：78.6 - 99.6）。
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