Shellabarger C J, Stone J P, Holtzman S
Cancer Res. 1976 Mar;36(3):1019-22.
When young female A X C rats were given 9.6 rads of 0.43-MeV neutrons, 32 of 33 survived a 50-week follow-up period, 2 rats developed a total of 3 mammary adenocarcinomas, and 3 rats developed a total of 4 mammary fibroadenomas. For 25 rats implanted with a 20-mg pellet containing 5 mg diethylstilbestrol and 15 mg cholesterol, average survival was 284 days; 22 rats developed a total of 182 mammary adenocarcinomas, and 21 rats developed a pituitary tumor. When diethylstilbestrol was given 2 days before neutron radiation to 35 rats, the average survival was 239 days; 32 rats developed a total of 842 mammary adenocarcinomas, 1 rat developed a single mammary fibroadenoma, and 34 rats developed a pituitary tumor. All of the 31 control rats survived the 50-week study period, and none developed tumors. Twenty-one of the rats that received both diethylstilbestrol and neutron radiation and 1 rat that received only diethylstilbestrol exhibited a multiple mammary adenocarcinoma response with a range of 18 to 72 mammary adenocarcinomas per rat. These results were interpreted to mean that a synergistic interaction between diethylstilbestrol and neutron radiation on mammary adenocarcinoma formation occurs in terms of an earlier onset and a larger number of mammary adenocarcinomas. These results confirm and complement a previously reported synergistic interaction between diethylstilbestrol and X-radiation on mammary adenocarcinoma formation in A X C female rats.
给年轻的雌性A×C大鼠照射9.6拉德的0.43兆电子伏中子后，33只中有32只在50周的随访期内存活，2只大鼠共发生3例乳腺腺癌，3只大鼠共发生4例乳腺纤维腺瘤。给25只植入含5毫克己烯雌酚和15毫克胆固醇的20毫克药丸的大鼠，平均存活时间为284天；22只大鼠共发生182例乳腺腺癌，21只大鼠发生垂体瘤。在对35只大鼠进行中子辐射前2天给予己烯雌酚，平均存活时间为239天；32只大鼠共发生842例乳腺腺癌，1只大鼠发生1例乳腺纤维腺瘤，34只大鼠发生垂体瘤。31只对照大鼠在50周的研究期内存活，无一发生肿瘤。接受己烯雌酚和中子辐射的21只大鼠以及仅接受己烯雌酚的1只大鼠表现出多发性乳腺腺癌反应，每只大鼠的乳腺腺癌数量在18至72例之间。这些结果被解释为意味着己烯雌酚和中子辐射在乳腺腺癌形成方面存在协同相互作用，表现为发病更早且乳腺腺癌数量更多。这些结果证实并补充了先前报道的己烯雌酚和X射线在A×C雌性大鼠乳腺腺癌形成方面的协同相互作用。
