Shellabarger C J, Chmelevsky D, Kellerer A M, Stone J P, Holtzman S
J Natl Cancer Inst. 1982 Nov;69(5):1135-46.
Mammary tumorigenesis was studied in female ACi rats after treatment with X-irradiation or neutron-irradiation, with or without diethylstilbestrol (DES) treatment. The mortality-corrected cumulative tumor rate based on all mammary neoplasms and the mortality-corrected incidence based on the first neoplasms only have been derived. In non-DES-treated animals, at the relatively high radiation doses studied, all dose-effect relationships were consistent with relative biological effectiveness (RBE) values slightly in excess of 10. In DES-treated rats definite findings were observed at neutron doses as low as 0.01 Gy (1 rad). The dose-effect relationship in DES-treated rats showed a strong sublinearly (dose exponent less than 1) at low neutron doses. RBE values in DES-treated rats increased in inverse proportion to the square root of the neutron dose, and exceeded 100 at a neutron dose of 0.01 Gy (1 rad).
在雌性ACi大鼠中，研究了X射线照射或中子照射（有无己烯雌酚（DES）治疗）后的乳腺肿瘤发生情况。得出了基于所有乳腺肿瘤的死亡率校正累积肿瘤发生率以及仅基于首个肿瘤的死亡率校正发病率。在未接受DES治疗的动物中，在所研究的相对高辐射剂量下，所有剂量效应关系均与相对生物效应（RBE）值略高于10一致。在接受DES治疗的大鼠中，在低至0.01 Gy（1拉德）的中子剂量下观察到明确结果。接受DES治疗的大鼠中的剂量效应关系在低中子剂量下显示出强烈的亚线性（剂量指数小于1）。接受DES治疗的大鼠中的RBE值与中子剂量的平方根成反比增加，并且在0.01 Gy（1拉德）的中子剂量下超过100。
