Shellabarger C J, Stone J P, Holtzman S
J Natl Cancer Inst. 1978 Dec;61(6):1505-8.
Young adult female rats of either the Sprague-Dawley stock or the ACI strain were each given an implant of a compressed pellet of 5 mg diethylstilbestrol (DES) and 15 mg cholestrol 2 days before irradiation with 0.4, 1.3, or 4.0 rads of 0.43-MeV neutrons. These rats were studied, along with appropriate irradiated and nonirradiated controls, until death or for a maximum of 48 weeks. Response differences between the strain and stock included the following: DES produced both pituitary tumors and mammary adenocarcinomas (MAC) in ACI rats only. Neutron radiation increased mammary fibroadenoma (MFA) formation in Srague-Dawley rats only. No interactions between DES and radiation on MAC formation in Sprague-Dawley rats or MFA formation in ACI rats were demonstrated. However, when DES and neutron radiation were combined, DES appeared to inhibit the MFA response to radiation in Sprague-Dawley rats. In contrast, DES appeared to act synergistically with neutron radiation on MAC formation in ACI rats. These results clearly demonstrate rat differences in mammary gland carcinogenesis in response to estrogen, to radiation, or to a combination of both agents.
在接受0.4、1.3或4.0拉德的0.43兆电子伏特中子照射前2天，给斯普拉格-道利品系或ACI品系的成年雌性大鼠分别植入含5毫克己烯雌酚（DES）和15毫克胆固醇的压缩丸剂。对这些大鼠以及适当的照射和未照射对照进行研究，直至死亡或最长48周。品系和品系之间的反应差异如下：DES仅在ACI大鼠中诱发垂体肿瘤和乳腺腺癌（MAC）。中子辐射仅增加斯普拉格-道利大鼠乳腺纤维腺瘤（MFA）的形成。未证明DES与辐射对斯普拉格-道利大鼠MAC形成或ACI大鼠MFA形成有相互作用。然而，当DES与中子辐射联合使用时，DES似乎抑制了斯普拉格-道利大鼠对辐射的MFA反应。相反，DES似乎与中子辐射在ACI大鼠的MAC形成上起协同作用。这些结果清楚地表明，大鼠在乳腺致癌作用中对雌激素、辐射或两种因素的联合作用存在差异。
