Jones G
J Pathol. 1975 Jun;116(2):101-5. doi: 10.1002/path.1711160206.
A histochemical study of plasma-membrane associated enzymes in rat liver demonstrated a significant lesion 3 days after a single oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin). The complete loss of canalicular ATPase reaction in the parenchymal cells of the centrilobular zone remained the prominent feature of the liver throughout the 6-wk period studied. Involvement of the periportal and midzonal regions occurred in moribund animals and improvement in the health of two surviving animals at 9 mth was associated with a normal distribution of ATPase in the liver. Qualitative changes in 5-nucleotidase and acid phosphatase were secondary to the parenchymal cell damage. This lesion supports the morphological evidence, reported previously, that the parenchymal cell plasma-membrane is a specific subcellular site of the toxic action of dioxin.
一项关于大鼠肝脏中与质膜相关酶的组织化学研究表明，单次口服剂量的2,3,7,8-四氯二苯并对二恶英（二恶英）3天后出现明显损伤。在整个6周的研究期间，小叶中心区实质细胞中胆小管ATP酶反应完全丧失仍然是肝脏的突出特征。濒死动物的门静脉周围和中区区域也受到影响，9个月时两只存活动物健康状况的改善与肝脏中ATP酶的正常分布有关。5-核苷酸酶和酸性磷酸酶的定性变化继发于实质细胞损伤。这一损伤支持了先前报道的形态学证据，即实质细胞质膜是二恶英毒性作用的特定亚细胞部位。
