Serban Radu, Grigorescu-Sido Paula, Gheban Dan, Kiss Eva
1st Pediatric Clinic, University of Medicine and Pharmacy, Str. Motilor no. 68, 3400 Cluj-Napoca, Romania.
Rom J Gastroenterol. 2002 Dec;11(4):297-301.
Helicobacter pylori (Hp) infection is involved in both digestive and extradigestive diseases. Endoscopically, antral location of gastritis, as well as antral nodularity, a consequence of the development of lymphoid follicles in the mucosa of this area, are considered by some authors specific for gastritis in children. Histologically, lymphoid follicles, noticed usually in children, are considered pathognomonic.
To establish prevalence of gastritis in children and the correlation between of endoscopical and histological findings.
The study group included 267 children in whom upper digestive endoscopy was performed for digestive symptoms. The diagnosis of Hp infection was based on the concordance between the positive urease test and the histological examination (documenting the presence of Hp in the gastric mucosa).
Endoscopical aspect of antral nodular gastritis was mainly found in children infected with Hp. Follicular gastritis, considered the histological marker of nodular gastritis, was also revealed in congestive gastritis. Patients infected with Hp most often displayed chronic gastritis and noninfected patients acute gastritis. Hp was not found in gastric mucosa without histological changes.
Nodular pattern of antral mucosa might be considered specific for Hp infection in childhood. In patients infected with Hp chronic gastritis was mainly found while in noninfected children acute gastritis was usually revealed. Hp was not found in gastric mucosa without histological changes.
幽门螺杆菌（Hp）感染与消化系统疾病和非消化系统疾病均有关。在内镜检查中，一些作者认为胃窦部胃炎的位置以及胃窦部结节形成（该区域黏膜淋巴滤泡发育的结果）是儿童胃炎的特异性表现。在组织学上，通常在儿童中发现的淋巴滤泡被认为具有病理诊断意义。
确定儿童胃炎的患病率以及内镜检查和组织学检查结果之间的相关性。
研究组包括267名因消化系统症状接受上消化道内镜检查的儿童。Hp感染的诊断基于尿素酶试验阳性与组织学检查结果的一致性（证明胃黏膜中存在Hp）。
胃窦结节性胃炎的内镜表现主要见于感染Hp的儿童。滤泡性胃炎被认为是结节性胃炎的组织学标志，在充血性胃炎中也有发现。感染Hp的患者最常表现为慢性胃炎，未感染的患者则为急性胃炎。在无组织学改变的胃黏膜中未发现Hp。
胃窦黏膜的结节样改变可能被认为是儿童Hp感染的特异性表现。感染Hp的患者主要表现为慢性胃炎，而未感染的儿童通常表现为急性胃炎。在无组织学改变的胃黏膜中未发现Hp。
