Chang Y H
J Pharmacol Exp Ther. 1975 Jul;194(1):154-8.
Colchicine and N-desacetyl-N-methylcolchicine suppressed both the reversed passive Arthus reaction and the carrageenan-induced edema in the rat. Colchicine, 2-desmethyl-colchicine glucoside and trimethylcolchicine acid had no effect on either model of inflammation. The ability or inability of these compounds to suppress the development of experimental inflammation correlated with their antimitotic activities. The findings lend support to the hypothesis that the anti-inflammatory and the antimitotic effects of colchicine may depend on the same basic, biophysical mechanism of action, i.e., the disruption of the microtubules.
秋水仙碱和去乙酰基-N-甲基秋水仙碱可抑制大鼠体内的被动反向Arthus反应和角叉菜胶诱导的水肿。秋水仙碱、2-去甲基秋水仙碱葡萄糖苷和三甲基秋水仙碱酸对这两种炎症模型均无作用。这些化合物抑制实验性炎症发展的能力与它们的抗有丝分裂活性相关。这些发现支持了这样一种假说，即秋水仙碱的抗炎和抗有丝分裂作用可能依赖于相同的基本生物物理作用机制，即微管的破坏。
