Feng Z H, Cheng S
Department of Biophysics, Beijing Medical University, Beijing 100083.
Sheng Li Ke Xue Jin Zhan. 1999 Jan;30(1):23-8.
Oxysterols, being oxygenated derivatives of cholesterol, are as many kinds as one hundred. They are found in the foodstuffs, the blood and arterial tissues of animals with hypercholesterolemia, the human atheroma, the foam cell from atherosclerotic tissues, as well as in the oxidized low density lipoprotein. The results of experiments have demonstrated that oxysterols are cytotoxic and they are injurious to a variety of cells including vascular endothelial cells, smooth muscle cells and monocyte/macrophages, suggesting that oxysterols could play a key role in the initiation and pathogenesis of atherosclerosis.
氧化甾醇是胆固醇的氧化衍生物，种类多达一百种。它们存在于高胆固醇血症动物的食物、血液和动脉组织、人类动脉粥样硬化斑块、动脉粥样硬化组织中的泡沫细胞以及氧化型低密度脂蛋白中。实验结果表明，氧化甾醇具有细胞毒性，对包括血管内皮细胞、平滑肌细胞和单核细胞/巨噬细胞在内的多种细胞都有损伤作用，这表明氧化甾醇可能在动脉粥样硬化的起始和发病机制中起关键作用。
