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[硬皮病性肢端综合征]

[Sclerodermic acrosyndromes].

作者信息

Carpentier Patrick H

机构信息

Unité de médecine vasculaire Hôpital Michallon 38043 Grenoble.

出版信息

Rev Prat. 2002 Nov 1;52(17):1891-5.

Abstract

In patients with systemic sclerosis, two main subsets of vascular acrosyndromes can be found: Raynaud's phenomenon and digital ulcerations. A severe Raynaud's phenomenon is found in almost every patient with systemic sclerosis. Most often, it is the first sign announcing the emergence of the disease and the hypothesis of subclinical scleroderma should be evaluated in every patient with apparently isolated Raynaud's phenomenon. Digital ulcerations can show several clinical aspects: ischemic micro-ulcerations and pitting scars of the finger tips, nailbed and nailfold lesions and digital necrosis, but also chronic ulcerations of the dorsal skin surface of the finger joints and ulcerated dermal calcifications, the origin of which is not only ischemic. First line treatment of such acro-syndromes is based upon cold avoidance and calcium-blocking agents. In the most severe cases, hospitalization in specialized centers is required, where customized physiotherapy and perfusions of prostaglandins or dextrans will be performed.

摘要

在系统性硬化症患者中,可发现两种主要的血管性肢端综合征亚型:雷诺现象和指端溃疡。几乎每位系统性硬化症患者都存在严重的雷诺现象。通常,它是该疾病出现的首个迹象,对于每一位仅有雷诺现象的患者,都应评估其亚临床硬皮病的可能性。指端溃疡可呈现多种临床症状:指尖的缺血性微溃疡和点状瘢痕、甲床及甲襞病变以及指端坏死,还包括手指关节背侧皮肤表面的慢性溃疡和溃疡性皮炎钙质沉着,其病因不仅限于缺血性。此类肢端综合征的一线治疗基于避免寒冷和使用钙通道阻滞剂。在最严重的病例中,需要在专业中心住院治疗,在那里将进行定制的物理治疗以及前列腺素或右旋糖酐灌注治疗。

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