Chalupná P, Lukás M, Adamec S, Sroubková R, Antosová M, Romaniv S
Gastroenterologické centrum IV. interní kliniky 1. LF UK a VFN, Praha.
Cas Lek Cesk. 2002 Nov 8;141(22):715-7.
A 29-year-old male patient with the anamnesis of inflammatory bowel disease and Grave-Basedowov disease was hospitalized because of rapidly spreading skin defect with affected muscle on the left shin. This skin defect appeared after the significant decreasing of corticoids. The small skin trauma preceded the pyoderma gangrenosum. First the skin disease was not right diagnosed and patient was cured by the excision of the defect. It caused tissue disintegration, muscle necrosis and extension of the defect. The whole leg was endangered. Patient was cured with corticoids and cyclosporin A after the right diagnosis. The defect healed and laboratory inflammatory markers decreased. The immunosuppresive therapy was changed to azathioprin, the corticoid therapy was interrupted. After three months the defect was healed.
一名29岁男性患者，有炎症性肠病和格雷夫斯-巴塞多病病史，因左小腿皮肤缺损迅速蔓延并累及肌肉而住院。这种皮肤缺损在皮质类固醇显著减少后出现。在坏疽性脓皮病之前有轻微的皮肤创伤。起初皮肤病未被正确诊断，患者通过切除缺损治愈。这导致了组织崩解、肌肉坏死和缺损扩大。整条腿都受到了威胁。在正确诊断后，患者接受皮质类固醇和环孢素A治疗后痊愈。缺损愈合，实验室炎症指标下降。免疫抑制治疗改为硫唑嘌呤，皮质类固醇治疗中断。三个月后缺损愈合。
