Westerhof W, Gamei M
Netherlands Institute for Pigment Disorders and Department of Dermatology, IWO-Building/Academic Medical Centre, University of Amsterdam, Meibergdreef 35, The Netherlands.
Br J Dermatol. 2003 Jan;148(1):80-5. doi: 10.1046/j.1365-2133.2003.05068.x.
Acquired junctional melanocytic naevi are harmless pigmented lesions of the epidermis, which can be of cosmetic concern. Various therapeutic approaches have been used in the treatment, but all these methods produce postoperative scarring or alterations in skin texture. Pigment laser treatment of benign pigmented lesions has shown a low potential for scarring by selectively targeting melanosomes in melanocytes and keratinocytes.
To find a fast, effective and safe treatment for the removal of acquired junctional melanocytic naevi.
PATIENTS/METHODS: We first studied the effect of the Q-switched and normal mode ruby laser on 12 patients (eight women and four men) with acquired melanocytic naevi. The effect was monitored by histology and clinical photography.
If the response to one treatment with the Q-switched laser mode was not completely effective, the lesions were subsequently treated with one or two sessions with the laser in normal mode. All flat lesions responded completely. After a follow-up period of 1 year they had not recurred. Slightly elevated lesions showed only a partial response, e.g. disappearance of the junctional part of the naevus but recurrence of the dermal part of the naevus. Red-brown junctional naevi as seen in skin types I and II did not respond well to ruby laser treatment.
The Q-switched ruby laser was very successful in completely removing flat (non-palpable) acquired junctional melanocytic naevi, but not compound naevi, with one to three treatment sessions, without any scarring or pigmentary disturbance.
获得性交界性黑素细胞痣是表皮无害的色素性病变,可能会影响美观。治疗中已采用了多种方法,但所有这些方法都会导致术后瘢痕形成或皮肤质地改变。通过选择性地靶向黑素细胞和角质形成细胞中的黑素小体,色素激光治疗良性色素性病变显示出较低的瘢痕形成可能性。
寻找一种快速、有效且安全的方法来去除获得性交界性黑素细胞痣。
患者/方法:我们首先研究了调Q模式和普通模式红宝石激光对12例(8名女性和4名男性)获得性黑素细胞痣患者的治疗效果。通过组织学检查和临床摄影对效果进行监测。
如果调Q激光模式单次治疗效果不完全理想,随后对病变采用普通模式激光进行一至两次治疗。所有扁平病变均完全消退。随访1年后未复发。轻度隆起的病变仅部分消退,例如痣的交界部分消失,但痣的真皮部分复发。在I型和II型皮肤中出现的红棕色交界痣对红宝石激光治疗反应不佳。
调Q红宝石激光能非常成功地通过一至三次治疗完全去除扁平(不可触及)的获得性交界性黑素细胞痣,但对复合痣无效,且无任何瘢痕形成或色素紊乱。