VentrAssist植入式旋转血泵中溶血的评估。

Evaluation of hemolysis in the VentrAssist implantable rotary blood pump.

作者信息

James Natalie L, Wilkinson Carmel M, Lingard Nicole L, van der Meer Anita L, Woodard John C

机构信息

VentrAssist Division, Ventracor Ltd., Chatswood, Sydney, New South Wales, Australia.

出版信息

Artif Organs. 2003 Jan;27(1):108-13. doi: 10.1046/j.1525-1594.2003.07188.x.

DOI:10.1046/j.1525-1594.2003.07188.x

PMID:12534722

Abstract

The VentrAssist implantable rotary blood pump (IRBP) is an implantable centrifugal blood pump with a hydrodynamically suspended impeller; optimal efficiency requires small running clearances (70-300 microm). The effect of running clearance and polish on hemolysis was evaluated in vitro. Three different human blood suspensions were compared: phosphate buffered saline (PBS), plasma volume expander (Hemaccel), and whole blood. The test conditions were: blood hematocrit 30%, flow rate 5 L/min, pressure across pump 100 mm Hg, 6 h flow period, and 37 degrees C. Normalized Index of Hemolysis (NIH) for the Biomedicus BP-80, used as a control, was: 0.0040 +/- 0.0023 (n = 9; x +/- SD) and 0.00014 +/- 0.00009 (n = 5) for pooled blood suspensions in PBS and Hemaccel respectively, and 0.00053 +/- 0.0002 (n = 3) in whole blood. Hemolysis was reduced by improved surface finish and unaffected by running clearance. NIH for the VentrAssist IRBP with 0.2 microm Ra surface finish was 0.000167 +/- 0.00007 (n = 4) g/100 L in whole human blood, demonstrating minimal hemolysis.

摘要

VentrAssist植入式旋转血泵（IRBP）是一种带有流体动力学悬浮叶轮的植入式离心血泵；最佳效率需要较小的运行间隙（70 - 300微米）。在体外评估了运行间隙和表面光洁度对溶血的影响。比较了三种不同的人体血液悬浮液：磷酸盐缓冲盐水（PBS）、血浆扩容剂（贺斯）和全血。测试条件为：血液血细胞比容30%、流速5升/分钟、泵两端压力100毫米汞柱、6小时流动期以及37摄氏度。用作对照的Biomedicus BP - 80的标准化溶血指数（NIH）为：在PBS和贺斯中的混合血液悬浮液分别为0.0040±0.0023（n = 9；x±标准差）和0.00014±0.00009（n = 5），在全血中为0.00053±0.0002（n = 3）。溶血通过改善表面光洁度而降低，且不受运行间隙的影响。表面光洁度为0.2微米粗糙度平均高度（Ra）的VentrAssist IRBP在全人血中的NIH为0.000167±0.00007（n = 4）克/100升，表明溶血极小。